Copyright © 2009  by "International Journal of Pharmaceutica Research and Development"  ·  All Rights reserved  ·  E-Mail: info@ijprd.com
Welcome to "International Journal of Pharmaceutical Research and Development"  i.e. "IJPRD"
HOW TO PREPARE   
YOUR PAPER
What's New | Feedback | Copyright and Disclaimer
TODAY IS
Abstract Content
Model Abstract
Summary Content
Model Summary

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Copyright © 2009  by "International Journal of Pharmaceutica Research and Development"  ·  All Rights reserved  ·  E-Mail: info@ijprd.com
Welcome to "International Journal of Pharmaceutical Research and Development"  i.e. "IJPRD"
HOW TO PREPARE   
YOUR PAPER
What's New | Feedback | Copyright and Disclaimer
Online Since : March 2009
TODAY IS
Abstract Content
Model Abstract
Summary Content
Model Summary

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
DESIGN AND IN VITRO EVALUATION OF MULTIPARTICULATE FLOATING DRUG DELIVERY SYSTEM OF GASTROPROKINETIC DRUG

Atul Eknath Wagh1*,
Vahbiz Patel1, Nidhi Sharma1, Jay Savai1, Meena Chintamaneni1

1IBSS College of Pharmacy, Malkapur Dist Buldana 443101 Maharashtra, India.
May - 2013 / Volume - 5/Issue - 3
( Total Articles =20)
May 2013 Issue
ABSTRACT
Mosapride citrate is a 5-HT4 agonist and its action must be targeted to the esophagus and the upper part of the stomach. The present work relates to development of multiparticulate floating drug delivery system based on gas generation technique to prolong the gastric residence time and to increase the overall bioavailability. Modified release dosage form of mosapride citrate adapted to release over a predetermined time period, according to biphasic profile of dissolution. The system consists of mosapride citrate layered pellets coated with effervescent layer and polymeric membrane. The floating ability and in vitro drug release of the system were dependent on amount of the effervescent agent (sodium bicarbonate) layered onto the drug layered pellets, and coating level of the polymeric membrane (Eudragit® NE 30D). The system could float completely within 5 min and maintain the floating over a period of 12 h. The multiparticulate floating delivery system of mosapride citrate with rapid floating and modified drug release was obtained.

KEYWORDS :
:  Gastroprokinetic  drug,  Swelling  index,  Hydrodynamically  balanced tablet.

[ Full Text - PDF ]
Share This Article on Social Networking's or You can invite friends to this Article.  !!