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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Copyright 2009  by "International Journal of Pharmaceutica Research and Development"    All Rights reserved    E-Mail: info@ijprd.com
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Online Since : March 2009
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF CARBAMAZEPINE IN BULK AND PHARMACEUTICAL PREPARATION

Santosh Kumbhar*1
,
Afroj Mulani2, Rohit Pawar1, Arvind Bendre1, Anup Dhange2, Pradip Salunkhe1

1
Department of Pharmaceutics, STES'S Sinhgad Institute of Pharmacy, Narhe,
Pune- 411041, Maharashtra.
May - 2013 / Volume - 5/Issue - 3
( Total Articles =20)
May 2013 Issue
ABSTRACT
A simple reverse phase liquid chromatographic method has been developed and subsequently validated for determination of Carbamazepine in tablet dosage form. The separation was carried out using a mobile phase containing methanol and Water with pH 3.5 adjusted by 20% of Phosphoric acid in the ratio of 80:20 v/v. Various types of analytical columns were tested for separation of carbamazepine. The good separation of chromatographic peaks was observed by using Intersil ODS C18 (150 4.6-mm, 5) column with flow rate of 1 mL / min using UV detection at 285 nm. The described method was linear over a concentration range of 3.12-25 g/mL (r2>0.9992). Separation was achieved within 5 min. The mean % recovery was found to be 100.27 % .The limit of detection (LOD) was found to be 0.25 g/mL. Whereas the limit of quantification (LOQ) was found to be 0.77 g/mL. The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise, accurate and cost effective which is useful for the routine determination of Carbamazepine in bulk drug and in its tablet dosage form.

KEYWORDS :
:  Carbamazepine, RP-HPLC, validation.

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