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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Copyright 2009  by "International Journal of Pharmaceutica Research and Development"    All Rights reserved    E-Mail: info@ijprd.com
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Online Since : March 2009
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
FORMULATION DEVELOPMENT AND EVALUATION OF IMMEDIATE DRUG RELEASE TABLET DOSAGE FORM OF SITAGLIPTIN PHOSPHATE

Sandeep Nyol
*1, M M Gupta

1
Department of pharmaceutics,
Jaipur College of Pharmacy, Jaipur, Rajasthan, India (302022)
May - 2013 / Volume - 5/Issue - 3
( Total Articles =20)
May 2013 Issue
ABSTRACT
The purpose of this research was to formulate and evaluate immediate drug release tablets of sitagliptin phosphate by direct compression method. Sitagliptin phosphate is as antidiabetic drug in type-II diabetes mellitus. Immediate release tablets were prepared by addition of different superdisintegrants. These superdisintegrants are crospovidone, sodium starch glycolate, croscarmellose sodium. All the powder blends and tablets were subjected to Pre-compression parameters, hardness, friability, weight variation, water absorption ratio, wetting time, disintegration time, drug content, in-vitro dissolution and short-term stability studies. Their results found satisfactory. Friability and weight variation of tablets were found in limits as per Indian Pharmacopoeia. Disintegration time of all batches was found near one minute. Percentage drug content of formulations was found in the range 98-102%. In-vitro dissolution studies in 0.1N HCl show the release 95-99% in the following order of superdisintegrants Croscarmellose > Sodium starch glycolate > Crospovidone. Maximum in-vitro dissolution was found with formulation batch F6 which having Croscarmellose as superdisintegrants. Short-term stability studies of optimized formulation F6 indicated that there were no significant changes in dosage form when changing temperature, humidity in three months. The optimum concentration of superdisintegrants used in various combinations results in the rapid swelling of tablet in dissolution medium, rapid disintegration and release drug release.

KEYWORDS : Sitagliptin phosphate, Immediate release, Superdisintegrants.

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