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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Copyright 2009  by "International Journal of Pharmaceutica Research and Development"    All Rights reserved    E-Mail: info@ijprd.com
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
EVALUATION OF ANTIRADICAL AND PASS PREDICTION BIO ACTIVITIES OF SCHIFF BASES DERIVED FROM 4-AMINOANTIPYRINE

Dr.G. Valli1*,
 
M.Mahalakshmi1

1
Department of chemistry,
S.F.R College for women, Sivakasi, Tamil Nadu, India.
May - 2013 / Volume - 5/Issue - 3
( Total Articles =20)
May 2013 Issue
ABSTRACT
Schiff bases derived from 4-aminoantipyrine plays a vital role in biological and pharmacological activities. Knowing the importance of 4-Aminoantipyrine Schiff bases and their analogues for their wide varieties of bioactivities like analgesic, antiviral, antipyretic, antirheumatic, antimicrobial, anti-inflammatory and CNS activities etc., our present study deals with the synthesis of  (E)-4-(4-hydroxybenzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one, (E)-4-(4-methoxybenzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one, (E)-4-(4-hydroxy-3-methoxybenzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one, (E)-4-((2-hydroxynarhthalen-1-yl)methyleneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one, (E)-4-(2-hydroxybenzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one and  (E)-1,5-dimethyl-4-(4-nitrobenzylideneamino)-2-phenyl-1H-pyrazol-3(2H)-one derived from 4-aminoanyipyrine with different aldehydes. Antiradical activity and PASS Prediction of bio activities were determined. In-vitro antiradical activities were determined by DPPH, NO and SO radical scavenging methods at a concentration of 100g/ml .The DPPH radical scavenging activity of (E)-4-(4-hydroxy-3-methoxybenzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one (91.57%) was  observed to be  closer to the  standard  ascorbic acid
. The NO radical scavenging activity of (E)-4-(4-hydroxybenzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one was found to exhibit 50% activity as that of ascorbic acid . The Super oxide radical scavenging of (E)-4-(4-hydroxy-3-methoxybenzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one  (61.74%),  (E)-4-(4-methoxybenzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one  (61.13%) were shown to be higher  than the standard  ascorbic acid (52%).
Among the six different schiff bases (E)-4-(4-hydroxybenzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one exhibited the maximum bioactivities like Antipyretic (96.4%), Insulysin inhibitor (94.9%) and Anti-inflammatory (91.9%), E)-4-(4-methoxybenzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one showed Antipyretic (91.4%), Insulysin inhibitor (9419%), CYP2A8 (93.9) and Anti-inflammatory (91.6%), (E)-4-(4-hydroxy-3-methoxybenzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one exhibited Antipyretic (96.8%) and Insulysin inhibitor (96.2%) and (E)-4-(2-hydroxybenzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one showed  Antipyretic (95.9%), Insulysin inhibitor (95.2%) and Anti-inflammatory (91.5%) compared to other bioactivities

KEYWORDS :
:  Antirdaical, PASS, DPPH, 4-aminoantipyrine

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