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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Copyright 2009  by "International Journal of Pharmaceutica Research and Development"    All Rights reserved    E-Mail: info@ijprd.com
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Online Since : March 2009
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
COMPARSION OF THREE PLATFORM TECHNOLOGIES: MICROSPHERES, INSITU IMPLANTS & SOLID IMPLANTS FOR LEUPROLIDE ACETATE

Sumit Shah1*,
Arvind G1, Noveen Konda1, Prashanth P1, Chandraswami1

1
Celon Laboratories Limited, Hyderabad, Andhra Pradesh, India.
May - 2013 / Volume - 5/Issue - 3
( Total Articles =20)
May 2013 Issue
ABSTRACT
Leuprolide acetate is an LHRH agonist analog that is useful in the palliative treatment of hormonal related prostate cancer, mammary cancer, endometriosis and precocious puberty.
Leuprolide acetate was prepared for controlled release of drug for a period of one month in the form of microspheres, in-situ implant and solid implant. Leuprolide acetate loaded microspheres were prepared by a double emulsion-solvent evaporation technique. In situ implant of Leuprolide acetate was prepared by polymer precipitation method. Solid implant of Leuprolide acetate was prepared by holt-melt excursion technology. Microspheres and solid implant having major drawback like cost and patient compliance as compare to in-situ implant. The characterization of all three platform technologies was carried out. In-Vitro release study of all three platform technologies was studied and it was observed that there was a significant difference in initial release of drug but more than 85% of drug was released after 28 days in all three platform technologies.

KEYWORDS : Leuprolide acetate, Microspheres, Insitu Implant, Solid Implant.

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