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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Copyright © 2009  by "International Journal of Pharmaceutica Research and Development"  ·  All Rights reserved  ·  E-Mail: info@ijprd.com
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Online Since : March 2009
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST SODIUM AND OLOPATADINE HYDROCHLORIDE IN BULK AND FORMULATED DOSAGE FORM.

Sucheta B Rananavare1*,
Dr.Vijay R Salunkhe1

1
Rajarambapu College of Pharmacy,
Kasegaon-415404,Maharashtra, India.
May - 2013 / Volume - 5/Issue - 3
( Total Articles =20)
May 2013 Issue
ABSTRACT
A simple, rapid, accurate, precise, and economic Spectrophotometric method for simultaneous estimation of montelukast sodium and olopatadine hydrochloride in bulk and formulated tablet dosage form has been developed. Method is based on solving simultaneous equation. Montelukast sodium and olopatadine hydrochloride shows absorbance maximum at 345 and 206 nm respectively, so absorbance was measured at the same wave lengths for the estimation of montelukast sodium and olopatadine hydrochloride
. Both drugs obey the beer lamberts’ law in the concentration range of 2-20µg/ml and 1-10µg/ml for montelukast sodium and olopatadine hydrochloride respectively. Method is validated according to ICH guideline and carried out for analysis of montelukast sodium and olopatadine hydrochloride in pure and formulated tablet dosage form.

KEYWORDS : Montelukast sodium, Olopatadine hydrochloride, New approved dosage form, UV-Spectrophotometer, Simultaneous equation, Validation.

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