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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Copyright 2009  by "International Journal of Pharmaceutica Research and Development"    All Rights reserved    E-Mail: info@ijprd.com
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Online Since : March 2009
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
SYNTHESIS OF NEW 9-(5-PHENYL-1H-ISOXAZOLINE-3-YL)-9H-  CARBAZOLE DERIVATIVES WITH POTENTIAL ANTI-  INFLAMMATORY ACTIVITY
       
Syed Azhar Nizami*1,

Marihal S.C1, Gurumurthy. M1, Kumar Prasad.S A2

*Dr HLT College of pharmacy, Kengal, Channapatana 562 160, Karnataka
May - 2013 / Volume - 5/Issue - 3
( Total Articles =20)
May 2013 Issue
ABSTRACT
Carbazole on reaction with Acetic anhydride in the presence of acetic acid and Zinc dust offereded 1-(9H-carbazole-9-yl)ethanone (1) condensation of (1) with various aromatic aldehydes offerded 1-(9H-carbazol-9-yl)-3-phenylpropyl-2-en-1-one (Chalcones, 1a-1j) . which on cyclization with Hydroxyl amine Hydrochloride yielded 9-(5-phenyl-1H-Isoxazoline-3-yl)-9H-carbazole (2a-2j). The structures of newly synthesized compounds were confirmed by FTIR, 1HNMR, MASS spectral data and elemental analysis. Compounds were screened for invitro anti inflammatory activity by Inhibition of Albumin Denaturation technique and invivo anti inflammatory activity by Carageenan induced Hind paw oedema method. All the synthesized substituted carbazoles have shown moderate to good anti inflammatory activity.

KEYWORDS : Carbazole, Acetic anhydride, Aromatic aldehydes, Hydroxylamine Hydrochloride, Anti inflammatory activity.

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