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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Copyright 2009  by "International Journal of Pharmaceutica Research and Development"    All Rights reserved    E-Mail: info@ijprd.com
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Online Since : March 2009
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
FORMULATION AND DEVELOPMENT OF TRANSDERMAL FILMS OF MELOXICAM WITH B-CYCLODEXTRIN COMPLEX AND ITS IN-VITRO RELEASE STUDIES

Manoj M Nitalikar1*,
Dinesh M. Sakarkar2

1
Research Scholar, Department of Pharmaceutical sciences,
Suresh Gyan Vihar University, Jaipur. (India)
2Department of Pharmaceutics,
Sudhakarrao Naik Institute of Pharmacy, Pusad, Dist. Yavatmal,(India)

June - 2013 / Volume - 5/Issue - 4
( Total Articles =20)
June 2013 Issue
ABSTRACT
Skin delivery of NSAIDs offers several advantages over the oral route associated with potential side effects. The present research has been undertaken with the aim to develop transdermal films of Meloxicam, which would attenuate the gastrointestinal relater toxicities associated with oral administration. Meloxicam is a nonsteroidal anti-inflammatory drug. It has anti-inflammatory, analgesic and antipyretic activity through inhibition of prostaglandinsynthetase, via inhibition of cyclooxygenase enzymes. This study was designed to enhance the solubility of Meloxicam by preparing its inclusion complex with -cyclodextrin and formulating films using HPMC E 6 and ethyl cellulose. The films were evaluated for release through cellophane membrane. It was observed that the formulation containing complex (DCP 3) was good in all respects.

KEYWORDS : Meloxicam, -cyclodextrin, Meloxicam--CD-Complex, films, cellophane membrane etc.
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